供应WHO18/248可溯源国际标准物质血管性血友病因子

供应WHO18/248可溯源国际标准物质血管性血友病因子

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The WHO 3rd International Standard (IS) for von Willebrand Factor, Concentrate was established by the Expert Committee on Biological Standardisation of the World Health Organisation in October 2021. The preparation consists of glass sealed ampoules (coded 18/248) containing 1 ml aliquots of von Willebrand factor concentrate, freeze-dried. The WHO 3rd IS is intended to be used for the estimation of von Willebrand factor in therapeutic concentrates via the calibration of working standards, such as manufacturers’ “in house” standards. The WHO 3rd IS has assigned values for the following analytes: WHO18/248

von Willebrand factor: antigen – VWF:Ag

von Willebrand factor: ristocetin cofactor – VWF:RCo

von Willebrand factor: collagen binding – VWF:CB

VWF binding to recGPIb – ristocetin-dependent – VWF:GPIbR

VWF binding to recGPIb – gain-of-function mutant – VWF:GPIbM

Further details on the preparation and the collaborative study can be found in the WHO document WHO/BS/2021.2408.

世界卫生组织生物标准化专家委员会于2021 10月制定了von Willebrand因子浓缩物的第三个世界卫生组织国际标准(IS)。该制剂由玻璃密封安瓿(编码18/248)组成,安瓿中含有1毫升冷冻干燥的von Willebrand因子浓缩液等分试样。世界卫生组织第三版IS旨在通过校准工作标准(例如制造商的“内部”标准)来估算治疗浓缩物中的冯·威莱布兰因子。世界卫生组织第三届IS为以下分析物赋值: 可溯源国际标准物质血管性血友病因子

血管性血友病因子:抗原-VWF:Ag

von Willebrand因子:ristocetin辅因子-VWF:RCo

血管性血友病因子:胶原结合-VWF:CB

VWF与recGPIb的结合-瑞司汀依赖性-VWF:GPIbR

VWF与recGPIb结合-功能获得突变体-VWF:GPIbM

有关制剂和合作研究的更多详细信息,请参阅世界卫生组织文件世界卫生组织/BS/2021.2408。