NIST- SRM 2921 Human Cardiac Troponin Complex
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This Standard Reference Material (SRM) is primarily intended for use in calibrating procedures and devices for the determination of cardiac troponin I (cTnI) in human serum. It can also be used for value-assignment of calibrators and control materials. A unit of SRM 2921 consists of five vials, each containing approximately 115 μL of a dilute solution of human cardiac troponin complex.
The troponin complex was purified from human heart tissue and consists of three subunits: troponin T (cTnT),troponin I (cTnI), and troponin C (cTnC). The choice of a human cardiac troponin complex was made with the assistance of the Cardiac Troponin I Standardization Subcommittee of the American Association for Clinical Chemistry (AACC). Through two interlaboratory comparison studies, various troponin preparations, including recombinant and native troponin complexes of the troponin T, troponin I, and troponin C subunits, recombinant troponin I/troponin C complex, and recombinant and native cTnI, were evaluated using fifteen commercial cTnI assays [1]. Based on the results of these interlaboratory comparison studies, the human cardiac troponin complex was chosen for its ability to harmonize clinical assays and for its commutability.
本标准参考物质（SRM）主要用于校准测定人体血清中肌钙蛋白I（cTnI）的程序和设备。它也可以用于校准品和控制材料的赋值。SRM 2921的一个单元由五个小瓶组成，每个小瓶含有约115μL的人心肌肌钙蛋白复合物稀释溶液。
肌钙蛋白复合物是从人类心脏组织中纯化的，由三个亚基组成：肌钙蛋白T（cTnT）、肌钙蛋白I（cTnI）和肌钙蛋白C（cTnC）。在美国临床化学协会（AACC）的肌钙蛋白I标准化小组委员会的协助下选择了人肌钙蛋白复合物。通过两项实验室间比较研究，使用15种商业cTnI测定法评估了各种肌钙蛋白制剂，包括肌钙蛋白T、肌钙蛋白I和肌钙蛋白C亚基的重组和天然肌钙蛋白复合物、重组肌钙蛋白I/肌钙蛋白C复合物以及重组和天然cTnI[1]。根据这些实验室间比较研究的结果，选择人肌钙蛋白复合物是因为其能够协调临床测定和可交换性。
Unit of Issue: 5 vials x 115 µL Human Cardiac Troponin Complex
Product Expiration Date: 30 June 2022
Revision History:11 June 2021 (Change of expiration date; editorial changes). NIST- SRM 2921
NIST Storage Temperature: Freezer (-80 o C)
Please see certificate for user storage information regarding this material.
Safety Information
Table(s) of Related Materials 105.01
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