208762-35-0/(1R,3S)-3-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopentanemethanol

分类：其他, 化学试剂, 医药类标准品

其他信息

名称	(1R, 3S)-3-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopentanemethanol
英文名称	(1R, 3S)-3-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopentanemethanol
中文名称	（1R，3S）-3-[2-氨基-6-（环丙基氨基）-9H-嘌呤-9-基]环戊烷乙醇
CAS号	208762-35-0
品牌	DBN
货号	A987623
规格	10mg, 25mg, 50mg, 100mg
储存温度	-20°C Freezer, U17Under Inert Atmosphere
货期	部分现货，详情请询
用途	仅供实验室使用
备注	(1R, 3S)-3-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopentanemethanol (Abacavir EP Impurity E) is an impurity of Abacavir (A104990). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.