((1S,4R)-4-(2-Amino-6-(((1R,4S)-4-(hydroxymethyl)cyclopent-2-en-1-yl)amino)-9H-purin-9-yl)cyclopent-2-en-1-yl)methanol

分类：其他, 化学试剂, 医药类标准品

其他信息

名称	((1S, 4R)-4-(2-Amino-6-(((1R, 4S)-4-(hydroxymethyl)cyclopent-2-en-1-yl)amino)-9H-purin-9-yl)cyclopent-2-en-1-yl)methanol
英文名称	((1S, 4R)-4-(2-Amino-6-(((1R, 4S)-4-(hydroxymethyl)cyclopent-2-en-1-yl)amino)-9H-purin-9-yl)cyclopent-2-en-1-yl)methanol
中文名称	（（1S，4R）-4-（2-氨基-6-（（1R，4S）-4-（羟甲基）环戊-2-烯-1-基）氨基）-9H-嘌呤-9-基）环戊-2-烯-1-基）甲醇
CAS号	NA
品牌	DBN
货号	A987661
规格	10mg, 25mg, 50mg, 100mg
储存温度	-20°C Freezer, U17Under Inert Atmosphere
货期	部分现货，详情请询
用途	仅供实验室使用
备注	(1S, 4R)-4-Amino-2-cyclopentene-1-methanol (-)-Dibenzoyl-L-tartaric Acid is an intermediate in synthesizing ent-Abacavir (Abacavir EP Impurity A) (A105015), an enatiomer of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.