151792-53-9/(1R,4S)-3-Oxo-2-azabicyclo[2.2.1]hept-5-ene-2-carboxylic acid 1,1-Dimethylethyl Ester

分类：其他, 化学试剂, 医药类标准品

其他信息

名称	(1R, 4S)-3-Oxo-2-azabicyclo[2.2.1]hept-5-ene-2-carboxylic acid 1, 1-Dimethylethyl Ester
英文名称	(1R, 4S)-3-Oxo-2-azabicyclo[2.2.1]hept-5-ene-2-carboxylic acid 1, 1-Dimethylethyl Ester
中文名称	（1R，4S）-3-氧代-2-氮杂双环[2.2.1]-庚-5-烯-2-羧酸1, 1-二甲基乙酯
CAS号	151792-53-9
品牌	DBN
货号	A987651
规格	10mg, 25mg, 50mg, 100mg
储存温度	-20°C Freezer, U17Under Inert Atmosphere
货期	部分现货，详情请询
用途	仅供实验室使用
备注	(1R, 4S)-3-Oxo-2-azabicyclo[2.2.1]hept-5-ene-2-carboxylic acid 1, 1-Dimethylethyl Ester is an intermediate in synthesizing ent-Abacavir (Abacavir EP Impurity A) (A105015), an enatiomer of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.