124752-25-6/Descyclopropyl Abacavir

分类：其他, 化学试剂, 医药类标准品

其他信息

名称	Descyclopropyl Abacavir
英文名称	Descyclopropyl Abacavir
中文名称	脱环丙基阿巴卡韦
CAS号	124752-25-6
品牌	DBN
货号	A987611
规格	10mg, 25mg, 50mg, 100mg
储存温度	-20°C Freezer, U17Under Inert Atmosphere
货期	部分现货，详情请询
用途	仅供实验室使用
备注	Descyclopropyl Abacavir (Abacavir EP Impurity C; Abacavir Related Compound A) is an intermediate of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.