168958-19-8/(1R,4R)-4-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-cyclopentene-1-carboxylic Acid Methyl Ester

分类：其他, 化学试剂, 医药类标准品

其他信息

名称	(1R, 4R)-4-[[(1, 1-Dimethylethoxy)carbonyl]amino]-2-cyclopentene-1-carboxylic Acid Methyl Ester
英文名称	(1R, 4R)-4-[[(1, 1-Dimethylethoxy)carbonyl]amino]-2-cyclopentene-1-carboxylic Acid Methyl Ester
中文名称	（1R，4R）-4-[（1, 1-二甲基乙氧基）羰基]氨基]-2-环戊烯-1-羧酸甲酯
CAS号	168958-19-8
品牌	DBN
货号	A987642
规格	10mg, 25mg, 50mg, 100mg
储存温度	-20°C Freezer, U17Under Inert Atmosphere
货期	部分现货，详情请询
用途	仅供实验室使用
备注	(1R, 4R)-4-[[(1, 1-Dimethylethoxy)carbonyl]amino]-2-cyclopentene-1-carboxylic Acid Methyl Ester is an intermediate in synthesizing trans-Abacavir Dihydrochloride (A104995), which is an impurity of Abacavir. Abacavir (A104990) is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.