| 名称 | rac 2-Azabicyclo[2.2.1]hept-5-en-3-one |
|---|---|
| 英文名称 | rac 2-Azabicyclo[2.2.1]hept-5-en-3-one |
| 中文名称 | rac 2-氮杂双环[2.2.1]庚-5-烯-3-酮 |
| CAS号 | 49805-30-3 |
| 品牌 | DBN |
| 货号 | A987600 |
| 规格 | 10mg, 25mg, 50mg, 100mg |
| 储存温度 | -20°C Freezer, U17Under Inert Atmosphere |
| 货期 | 部分现货，详情请询 |
| 用途 | 仅供实验室使用 |
| 备注 | rac 2-Azabicyclo[2.2.1]hept-5-en-3-one (Abacavir – In House Impurity) is a useful reagent in the synthesis of carbocyclic sugar amines, carbanucleosides, and carbocyclic dinucleotide analogues (1). rac 2-Azabicyclo[2.2.1]hept-5-en-3-one is also an intermediate of Abacavir (A104990), a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. |
